U0126,U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC?? = 72 nM) and MEK2 (IC?? = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.

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U0126,U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC?? = 72 nM) and MEK2 (IC?? = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.